PLAN FOR SOUTH CAROLINA’S RESPONSE

TO AN INFLUENZA PANDEMIC

 

April 3, 2000

 

TABLE OF CONTENTS

 

THE NEXT INFLUENZA PANDEMIC UNFOLDS………………………….

Page 3

I.

COMMAND, CONTROL, AND MANAGEMENT PROCEDURES……….

Page 4

II.

SURVEILLANCE……………………………………………………………..

Page 5

III.

VACCINE AND ANTIVIRAL DELIVERY……………………………………

Page 9

IV.

EMERGENCY RESPONSE…………………………………………………

Page 17

V.

COMMUNICATIONS………………………………………………………….

Page 19

APPENDICES

………………………………………………………………………………….

Page 21

 

The next influenza pandemic unfolds ...

 

An outbreak of unusually severe respiratory illness is identified in a small village in South China. At least 25 cases have occurred, affecting all age groups; 20 patients required hospitalization at the local provincial hospital, 5 of whom died from fulminant pneumonia and acute respiratory failure. Surveillance in surrounding areas increases, and new cases begin to be identified throughout the Province. Viral cultures collected from several of the initial patients are positive for type A influenza virus, but cannot be further subtyped by the Provincial or national laboratory with available reagents. The isolates are sent to the World Health Organization (WHO) Reference Center for Influenza at the Centers for Disease Control and Prevention (CDC), Atlanta, for further characterization. CDC determines, using special reagents, that the isolates are type A H7N1, a subtype never before isolated from humans. This information is immediately transmitted back to the Chinese Ministry of Health, and throughout the WHO network. CDC dispatches a team of epidemiologists and laboratory personnel to further study the epidemiologic and clinical features of the disease, and notifies quarantine stations and large hospitals at major U.S. ports of entry to be on the alert for arriving passengers with severe respiratory illness. Isolates of the new H7N1 strain are sent to the FDA to begin work on producing a reference strain for vaccine production, and influenza vaccine manufacturers are placed on alert. The novel influenza virus begins to make headlines in every major newspaper, and becomes the lead story on major news networks. Key U.S. government officials are briefed on a daily basis as surveillance is intensified throughout Southeast Asia and the Pacific Rim.

 

Over the next two months, outbreaks begin to appear in Hong Kong, Singapore, South Korea and Japan. Although cases are reported in all age groups, young adults appear to be the most severely affected, and case-fatality rates approach 5%. Widespread panic begins because vaccine is not yet available and supplies of antiviral drugs are severely limited. Several weeks later, the CDC reports that H7N1 virus has been isolated from ill airline passengers arriving from Hong Kong and Tokyo in Los Angeles, Honolulu, Chicago and New York. States and local areas are asked to intensify influenza surveillance activities and vaccine manufacturers are requested to go into full production.

 

A few more weeks pass and focal outbreaks begin to be reported throughout the United States. Rates of absenteeism in schools and businesses begin to rise. Phones at physician offices and health departments begin to ring constantly. The media reports exaggerated accounts of illness. Citizens begin to clamor for vaccine, but only 10% of the estimated needs are available. Police departments, local utility companies and mass transit authorities begin to have severe personnel shortages, resulting in severe disruption of routine services. Hospitals and outpatient clinics become severely short-staffed when physicians, nurses and other health-care workers become ill. Elderly patients with chronic, unstable medical conditions are afraid to venture out for fear of becoming seriously ill with influenza. Intensive care units at local hospitals become overwhelmed, and soon there are widespread shortages of mechanical ventilators for treatment of patients with pneumonia. Family members are distraught and outraged when loved ones die within a matter of a few days. Looting becomes a serious problem in major metropolitan areas due to shortages of police officers. Several major airports close because of high absenteeism among air traffic controllers. Further deterioration in health and other essential community services occurs over the next 6-8 weeks as illness sweeps across the country ....

 

Are you and others within your jurisdiction prepared?

 

I. COMMAND, CONTROL AND MANAGEMENT PROCEDURES

(“CONCEPT OF OPERATIONS”)

 

A.      Command and Management during a Pandemic

 

While the SC Emergency Operations Plan should be the basis for our Pandemic Plan, influenza pandemics present certain special challenges that must be addressed specifically, e.g. a special surveillance system, rapid delivery of vaccines and antiviral drugs and a plan for prioritization of recipients, legal authority to allocate these appropriately, etc. These unique aspects of an influenza pandemic should be addressed in an Annex to that SC EOP.

 

  1. When the “Pandemic Alert” stage has been declared, the Commissioner of Health and

Environmental Control in concert with the Director of Emergency Preparedness Division (EPD) and the Deputy Commissioner for Health, will designate a Pandemic Influenza Response Management Group (“Pandemic Response Group”, PRG) consisting of the following persons or their designees:   State Epidemiologist (Chair), representative of Emergency Preparedness Division (EPD), representative of the Governor’s Office, State Laboratory Director, Director of DHEC Immunization and Prevention Branch, two DHEC District Health Directors (DHDs), representative of SC Hospital Alliance (SCHA) , representative of SC Medical Association (SCMA), and the DHEC and/or EPD Public Information Officer.  

 

  1. This Group will be responsible for administering the State’s response to the pandemic through the “Pandemic Over” stage, including responsibility each of the Major Priority Activities presented below, including the State’s legal authority to allocate distribution of influenza vaccine and antiviral drugs.   Most of the necessary management activities will have to be done through working partnerships with health, medical, pharmacy, coroner, and emergency response organizations in the State, which the Group will be responsible for reactivating, or initiating if they have not already been addressed through this Plan.  The PRG will meet as frequently as needed to assure effective control and coordination of pandemic response activities, more often as the pandemic moves closer to the State.

 

  1. This Group through the Chair will be responsible for convening a Pandemic Response Team (PRT) to assist in the management of activities during the pandemic response, which will include staff from appropriate DHEC divisions and EPD, as allocated by Commissioner of DHEC and  Director of EPD.   An Administrative Coordinator (Operations Manager) will be assigned to the Team to explicitly track and follow up on assigned responsibilities assigned and provide administrative support.

 

  1. The PRG Chair will be responsible for regular communication with all involved state government organizations within and outside DHEC and EPD (“horizontal communication”), and for assuring that regular communication, information and instructions are provided to the South Carolina public on the progress and preparations for the pandemic.

 

  1. If the PRG determines that more staff assistance is required, they will submit a request to the DHEC Deputy Commissioner for Health Services for help, specifying what skills and numbers are needed.   After consideration of what ongoing activities must be continued, the Deputy Commissioner will re-assign staff to the PRG for the duration of the Pandemic.   During this period the PRG through the PST leader will be responsible for directing the duties of all reassigned employees.

 

  1. During the Pre-Pandemic Period, specific electronic Resource Lists of potential partnering organizations and persons for the pandemic stage will be developed and disseminated.  These will include name or organization/person, specific function relevant to a pandemic response, address or location, telephone/fax numbers, and e-mail address.  The following general categories  of resource organizations are available or should be developed:

 

Physicians by medical specialties, physicians volunteering for disaster service, infection control practitioners, district epi-teams, acute-care hospitals, chronic-care hospitals, federal and military hospitals, skilled nursing facilities, clinical laboratories and laboratory directors, National Guard medical units, DHEC health district offices, state emergency response regional offices, county emergency preparedness directors, county coroners and medical examiners, funeral homes and morticians, pharmacies by whether certified to give immunizations, members of state Rapid Response Teams,  DMAT, and DMORT Teams

 

 

II. SURVEILLANCE

 

Because the antigenic properties of influenza viruses are constantly changing, both virologic surveillance -- in which influenza viruses are isolated for antigenic and genetic analysis -- and disease surveillance -- in which the epidemiologic features and clinical impact of new variants are assessed -- should be viewed as equally critical for pandemic preparedness.

 

In the United States, international influenza surveillance activities are coordinated at the CDC by the WHO Collaborating Center for Influenza Reference and Research.  The CDC participates in WHO's global influenza network with approximately 110 national laboratories in over 80 countries and four International Reference Centers.  The CDC maintains frequent communications with WHO Headquarters in Geneva, with the other three WHO International Reference Centers, and with national laboratories worldwide concerning the numbers and types/subtypes of influenza viruses isolated and the extent of influenza like disease which taking place at the time of virus isolation.

 

A.      National Surveillance

 

National surveillance in the U.S. is also coordinated by CDC, with State and county health departments assuming primary responsibility for carrying out virologic, mortality, and morbidity components. These activities currently c                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                uenza-like illness (ILI) per total number of patient visits by age group each week; (4) Vital Statistics Offices of 122 U.S. cities which report, each week, the percentage of total deaths caused by influenza and pneumonia (ICD-9 codes 480-487); and (5) a variety of other sources which spontaneously report influenza outbreaks or other influenza-associated events.

 

B.      Routine Influenza Surveillance Activities in South Carolina

 

1.       Physician Reporting - Influenza-like illness (ILI) is one of the mandated reportable conditions in South Carolina; reporting is required by number only.  ILI reports, along with the Source County of the report, are entered into the disease surveillance data set and transmitted weekly to the CDC via the National Electronic Telecommunications System for Surveillance (NETSS).  Physician participation in this passive reporting system is generally poor.

2.       Viral isolates - The DHEC Division of Laboratories (DOL) is capable of performing influenza viral isolation and typing and subtyping for influenza A isolates.  They also perform influenza serodiagnosis by complement fixation testing of acute and convalescent sera.  DOL is currently the only in-state diagnostic lab that offers viral isolation.  Some out-of-state commercial labs may perform viral isolations for South Carolina physicians.  Laboratories are also required to report influenza isolates and serologies to DHEC, and these like ILI reports are transmitted to CDC via NETSS.

 

3.       Sentinel Surveillance Sites

 

a)       DOL coordinates the Influenza Surveillance Program for the 70 participating sentinel physicians, colleges, hospitals and local health departments.  Sites submit clinical samples for viral isolation and typing.  There is currently about 1 sentinel site per 50,000 population, which exceeds the national recommendation to establish one sentinel site per 250,000 population. 

b)       The DHEC Acute Disease Epidemiology Division has established a sentinel surveillance system for influenza in 65 elementary schools throughout the state (five schools in each of the 13 Health Districts).  Each week the participating schools fax reports that are compiled by the surveillance coordinator who monitors absenteeism looking for rates of 10% or greater lasting for several days.  Influenza is almost unique as a cause for high workplace and school absenteeism and this surveillance system therefore provides our most timely and geographically representative information about influenza circulation in the state.

 

C.       National activities to enhance surveillance

 

1.       Improve “early warning” and “readiness” capability - Although the basic influenza surveillance infrastructure in the U.S. has generally been adequate to monitor, on a "macro" level, the spread and impact of "drifted" strains, the sensitivity of detecting an isolated importation event is generally poor.  There is a need to enhance our surveillance activities to improve our ability to detect importation and initial spread of novel variants emerging from other countries.

 

2.       Ability to rapidly expand surveillance activities - Contingency plans for rapid expansion of the basic surveillance systems are necessary to provide the level of detail necessary to track the spread and impact of a pandemic variant in State and local communities and to modify control measures as needed.

 

3.       Improved ability to detect the emergence of novel variants in the U.S.  - Although most novel strains of influenza (pandemic variants) have emerged from China and the Pacific Rim, such variants could arise in the U.S.  Efforts are now underway at the national level and in selected States to examine the potential for highly pathogenic avian strains that are detected on poultry farms nationwide and among live bird markets to be transmitted to humans. CDC is also collaborating with USDA to determine if influenza viruses are being transmitted to humans from infected swine and horses during outbreaks of influenza-like disease in domestic farm animals.

 

DURING THE PRE-PANDEMIC PERIOD:

 

A.      Improve virologic surveillance capability - The DHEC DOL can identify and type influenza viruses and perform influenza A subtyping.  It is estimated that DOL’s viral isolation capacity is about 100 isolates per week.  The primary limitation is the availability of tissue culture media, which would have to be ordered two weeks in advance of the need.  Tissue culture could become limited in the event of a pandemic.  As the use of antiviral agents for the treatment and prophylaxis of influenza increase laboratories should address their capability to conduct testing and surveillance for resistant viral strains.

 

B.      Enhance Disease-based surveillance capability

 

  1. Annual mail-outs are conducted preceding each influenza season.  They briefly describe the reporting requirements for influenza and the rationale for surveillance.   In the future the threat of pandemic flu, and the important role of providers in surveillance will be included in these annual mailings.  The annual mail-outs also include information encouraging providers to offer influenza and pneumococcal vaccine to appropriate populations.  We have decided against the promotion of year-round influenza surveillance because of impressions that this could become too burdensome for disease reporters, or desensitize them to participating during peak influenza season.  Annual notices should explain that young adults have been more severely effected in pandemic years than in inter-pandemic periods and will be encouraged to consider influenza vaccination every year.
  2. The current sentinel-physician network, providing about one sentinel site per 50,000 of the state’s population, should be more than adequate.   If significant gaps are identified in the geographic representativeness of the sites, efforts will be made to enroll additional sites to cover gaps.  Additional sites using private sector employee health programs should be added, particularly those industries in the state that have an international base and large numbers of employees that travel widely.  They may serve as potential sources of influenza importations.

 

  1. District level responsibilities

 

a.       District Epi Teams will appoint an influenza surveillance coordinator in each district.  Each surveillance coordinator will be given a copy of the plan and information about influenza surveillance enhancements.  In the event of a novel virus alert this person will assume responsibility for supporting the enhanced surveillance activity in their district.  They will maintain communications with local disease reporters, serve as contacts for receiving surveillance data from additional reporting sites, and locally disseminate surveillance data.   This responsibility will be delegated in advance and back-up personnel will be identified in the event of staff absences.

 

b.       During any stage of influenza transmission clusters of upper respiratory ILI will be rapidly investigated and swabs for viral isolation will be collected to confirm or rule out influenza.  For influenza confirmed outbreaks the population at risk, attack rate, and vaccine efficacy, if applicable, will be defined.  For those outbreaks involving institutions education about future prevention will be provided.

 

4.       Identify additional sources of influenza surveillance data

 

a.       Travelling military personnel may be a potential source of importation of novel influenza strains.  Contacts will be established and maintained with the preventive medicine and hospital epidemiology programs at the state’s three military hospitals: Moncreif Army Community Hospital, Ft. Jackson, Shaw Air Force Base Hospital, and the Naval Hospital in Charleston.  Military medical facilities maintain their own disease surveillance systems.  Standard, routine reporting systems should be established between these facilities and DHEC.  This data should be included in the statewide surveillance data.

 

b.       Emergency Departments and Managed Care Organizations should be included in the enhanced surveillance activities.  Department heads affiliated with these should receive the annual communications described above that will be sent to private practice physicians.

 

c.       The Catawba Health District has initiated sentinel surveillance for influenza based in nursing homes in the district.  In this system DHEC provides influenza isolation kits to participating facilities and a point of contact for reporting clusters of ILI to DHEC has been established.  Other districts have been encouraged to develop similar systems. 

 

d.       Death Certificate Data – DHEC will request that the Office of Vital Records and Public Health Statistics generate a data set containing deaths coded as attributable to P and I. (ICD-9 codes 480-487).  The Board of Funeral Directors will be involved to emphasize the importance of timely and accurate completion of death certificates to enhance influenza mortality surveillance.

 

e.       Contacts will be established with state airports and shipping ports to develop plans for how to monitor for the possible importation of ILI in the event of the identification of a novel strain. 

 

C.      Develop enhanced electronic and telecommunications capability for compiling, transmitting and disseminating data.  This enhancement should address the handling of data at several levels:  

1)       Data transmittal within DHEC can be improved.  The DHEC Division of Acute Disease Epidemiology is pilot testing an electronic data transmittal of influenza viral isolation data from the DOL to the Acute Disease Epi Division.  This data is now used as a reference but if the pilot is successful, information about circulating strains could be transmitted electronically to each health district.  Health districts could them more easily distribute data to their local reporting partners.  Improved dissemination of influenza data would better serve health care providers at the local level and would probably stimulate additional reporting.  The electronic data could also be compiled in weekly summary reports.

2)       As much as possible all providers should be included in the surveillance communications loop.  Weekly summary reports of flu activity could also be distributed by local health departments to physician offices, hospitals ICPs, sentinel schools, nursing homes, health care centers in universities and in industry, and to health departments of neighboring states. Reports could be posted on the DHEC Web site. 

3)       DHEC DOL has the capability to maintain a statewide lab users group linked by e-mail to enhance communications among laboratories.

 

D.  Animal surveillance – Those in the state with expertise to monitor for avian, swine, and equine influenza should develop plans to monitor for clinically consistent clusters of illnesses in these animal groups and be vigilant for the potential for interspecies transmission.  The State Veterinarian should coordinate this with the Clemson Livestock and Poultry Lab and the State Public Health Veterinarian at DHEC. 

 

DURING THE NOVEL VIRUS ALERT:

 

A.      DHEC Acute Disease Epi Division will monitor bulletins from CDC regarding virologic, epidemiologic and clinical findings associated with new variants isolated within or outside the U.S.

 

B.      DHEC DOL will obtain appropriate reagents from CDC to detect and identify the novel strain if it is found to have the potential for sustained transmission in humans.  If other medical centers have developed the expertise for viral isolation, the influenza kits will also be distributed to all these sites.  If viral isolation capability is not widely available, state and local hospital labs will be encouraged to stock and use rapid antigen tests.  DOL will perform viral isolations to monitor the circulating strains in South Carolina and to detect any antigenic drift or shift in circulating strains.  The H and N types identified will be submitted to CDC.

 

C.      The appropriate partners and stakeholders in the pandemic influenza planning will meet within 2 weeks of the novel virus alert and review major elements of enhanced surveillance activities and modify and update plan as needed.

 

D.      To detect possible importation and local spread, the enhanced surveillance activities described above that have not already been implemented will be activated.  Those participants in enhanced surveillance will be notified to begin weekly reports to the identified points of contact on the District Epi Teams. Data about severe respiratory illness and unexplained deaths should be captured from local hospitals and nursing homes.  Surveillance for severe respiratory illnesses among travelers from geographic areas in which the novel strains have been isolated should be conducted.  Plans that have been put in place with South Carolina airports, airlines, and commercial and passengers shipping lines will be implemented by contacting the responsible parties with those entities.  All surveillance data will be transmitted to CDC via NETSS.  

 

E.   To keep communities informed and to prevent the dissemination of misinformation, media representatives should be involved in designing a plan for the collaborative dissemination of regular, relevant, and timely surveillance data to the general public from an official source.

 

DURING THE PANDEMIC ALERT:

 

DHEC has broad authority to implement the enhanced surveillance activities described above and to change reporting requirements to conduct adequate surveillance in the event of a pandemic flu alert.   Regulation 44-1-80 states:  “The Board of Health and Environmental Control…shall investigate the reported causes of communicable or epidemic disease and shall enforce or prescribe such preventive measures as may be needed to suppress or prevent the spread of such diseases by proper quarantine or other measures of prevention, as may be necessary to protect the citizens of the State.”

 

A.                  In the event of a pandemic flu alert, DHEC would change to designation of influenza to an urgently reportable condition.  Providers will receive notification of this change by DHEC communications with the Medical Association, Hospital Association, local medical societies, and special mailings.  DHEC would request daily reporting of the total number of P and I patients and total number of patients seen at emergency departments and large primary care practices.  The designated influenza surveillance coordinators of the District Epi Teams would assume the responsibility to be reassigned to specifically conduct and maintain enhanced surveillance activities.

 

B.                  Fully activate enhanced surveillance activities; assess functionality, timeliness and completeness of reporting (including "zero case" reporting), data entry and dissemination, and links and feedback at higher and local levels of the system. Include age group at each surveillance site; and characterize the denominator to have a better idea where to utilize vaccine.

 

C.                  Include airlines and airports in surveillance of persons travelling from geographic areas in which the novel strains have been isolated.

 

 

DURING THE PANDEMIC IMMINENT STAGE:

 

A.                  Implement and pilot-test final modifications, if any, in enhanced surveillance system. Monitor the ability of hospitals and outpatient clinics to cope with increased patient loads,

 

B.                  In collaboration with CDC and other groups at the national level, consideration would be given to any special studies that could be conducted without further compromising the anticipated limited resources.  Special studies might include some of the following:

 

1)       collecting data to document outbreaks of influenza in different population groups

2)       determining age-specific attack rates, morbidity and mortality

3)       working with health care providers and pathologists to collect data about any unusual clinical syndromes associated with influenza infection (as well as risk factors for those syndromes and appropriate treatment), or unusual pathologic features associated with fatal cases

4)       conduct efficacy studies of vaccination or chemoprophylaxis

5)       assess the effectiveness of traditional control measures such as school and business closings

6)   assess the medical, social and economic impact of the pandemic

 

III. VACCINE AND ANTIVIRAL DELIVERY

 

Background

 

 Since its development more than 50 years ago, influenza vaccine has been the cornerstone of influenza prevention and control. Vaccination will also serve as the central preventive strategy during the next pandemic.

 

The World Health Organization (WHO) collaborating influenza centers detect and monitor new variants of influenza virus throughout the year for potential inclusion in the next year's vaccine. Vaccine strains are chosen by spring. The four licensed U.S. manufacturers make ~70-80 million doses over the winter through summer months and the vaccine is administered, primarily to "high risk" patients (as currently defined by the Advisory Committee on Immunization Practices), from September through January. Approximately 90% of all doses are administered through the private sector, with most States and counties offering relatively small amounts of vaccine through publicly funded programs. This system has served the American public well -- with record levels of vaccination coverage during the 1990's-- and continues to improve over time.

 

Despite our ongoing improvements in the manufacturing and delivery of annual flu vaccine the next pandemic will pose a number of challenges, particularly to State and local health departments which clearly must serve as the "linchpin" of vaccination delivery efforts:

 

·         The target population for vaccination will be expanded far beyond the typical "high-risk" groups to encompass, ideally, the entire U.S. population.

·         The "warning period" preceding spread of the pandemic strain in the U.S. is likely to be relatively short, so that vaccine will have to be distributed and administered as rapidly as possible.

·         It is likely that a severe and/or moderate vaccine shortage will exist, especially early on during the course of the pandemic. Moreover, it is possible that no vaccine will be available.

·         The emergence of a pandemic strain will likely require a second dose of vaccine ~30 days later.

 

It is likely that the public sector will take responsibility for vaccinating health care workers, other "first responders", certain essential community servants, and the poor and the uninsured.

 

       Success of the pandemic vaccination program will be determined in large part by the strength of State and local vaccination programs during the inter-pandemic period.  Public confidence in the benefits of influenza vaccine must continue to improve, and there must be increased emphasis on the use of pneumococcal vaccine. Current coverage levels among high-risk persons are only 15-45% for pneumococcal vaccine and 27-65% for influenza vaccine. To ensure more routine acceptance of influenza vaccine, consideration should be given to expansion of immunization promotion activities, to include media involvement. If additional public funds are available to purchase and administer pneumonia vaccine, these should be targeted to reach persons in “high-risk” groups, including those under age 65 with chronic medical conditions.

 

Assumptions

 

1.       All persons will be susceptible

2.       Due to vaccine shortage, a priority list of vaccinees will need to be developed and adhered to.

3.       One month’s supply of vaccine will cover at most 20% of the state’s population.

4.       At least the first month’s supply of vaccine will be purchased federally and distributed to the states.

5.       All vaccine available to the state may arrive via a single allotment.

6.       Two doses of vaccine will be required per person vaccinated

7.       There may be up to 40% attrition of essential personnel in the health care delivery sector.

8.       Vaccine delivery will take priority over antiviral delivery.

9.       Federal government’s stated responsibilities during a pandemic will be fulfilled, to include point #4

 

Goals (in order of priority)

 

1.       Efficient and rapid allocation, distribution, and administration of vaccine to officially designated high priority groups

2.       High rates of second dose completion (target 80% of high priority groups)

3.       Prompt reallocation and redistribution of unused vaccine (though there may be little or none)

 

Vaccine Delivery

 

Direction and Control of Vaccination Activities

 

Responsible Authority: DHEC Division of Immunization. Will be responsible for:

 

1.       Command and Control Functions, including:

 

·         Assurance of redundancy

·                                                                                             Communication within  the overall pandemic command structure

·                                                                                             Assurance of legal authority for pandemic immunization activities

(Statute 44-29-210: Physicians, registered nurses and certain authorized public health employees participating in mass immunization projects exempt from liability)

·                                                                                             Coordination of vaccination activities with neighboring states and with groups such the VA hospitals, IHS, military installations, etc.

 

2.       Acting as a center for vaccine inventories and distribution

 

3.       Maintaining supplies of federally distributed vaccine in central and ancillary storage facilities.

 

Ultimate responsibility for above would rest with a “vaccine controller” who, along with a designated back up in case of illness, would oversee distribution of available vaccine and verify that vaccine is being provided to priority groups.

 

Vaccine Purchase for Public Sector Programs

 

The Immunization Division has already stated its willingness to purchase vaccine during a pandemic for use by both the public and private sector.  The amount obtained will need to be increased far above the current levels of influenza vaccine purchase; however, the ability to purchase vaccine may be limited by shortages of supply (though all states likely to receive some doses of vaccine), available storage, and the amount of supplementary Federal funding available. The purchase of vaccine using state funds may not be necessary until the second month of a pandemic and may NOT be an option due to lack of vaccine availability. 

 

Health Department vaccine purchase will need to take priority over private sector purchase in a vaccine shortage scenario. The possibility of vaccine reallocation to the private sector AFTER priority public health activities have been accomplished should be anticipated. This would best be accomplished by using the existing VAFAC vaccine distribution network.

 

Setting Vaccination Priorities

 

There should be a standing group of advisors to the governor’s office to determine lists of priority groups for vaccination. The proposed structure will be similar to that of a hospital ethics board. The “Vaccine Priority Group” (VPG) will need to acknowledge that their decisions center around potentially conflicting values and that a key question to address will be “What are we hoping to prevent?” (Death, serious illness, overall burden of illness, economic and productivity loss) The advisory group should be broadly representative and should include epidemiologists, other public health officials, ethicists, the faith community, representatives of the medical community, business, law enforcement, transportation, and citizens. The body’s makeup will be determined in advance of the pandemic. The planning process should be presented to legislators.

 

The advisory group should generate more than one plan for vaccine prioritization based on at least three scenarios: severe or moderate vaccine shortage or no vaccine shortage. Several lists of priority groups should be developed, rather than a single one, since the epidemiologic characteristics of a pandemic strain cannot now be predicted. If spread proceeds West to East, information about what population groups are at highest risk will likely be available. It should be acknowledged that the order of priority may change when the characteristics of the pandemic strain are better defined. Decisions must involve overall pandemic command/control structure.

 

“Essential service workers” will be defined and prioritized as part of the above process; examples identified from both planning workgroups include health care workers, EMS, essential public service personnel such as public utility workers, police and fire personnel, utility workers and public and private transportation workers. Very specific lists of personnel will need to be developed and prioritized with input from all parties so that no essential community workers are overlooked and “fall between the cracks”. For example, severe illness among funeral service personnel could have severe consequences for public morale and potentially for the public’s health as well. Within priority groups, highest priority subgroups should be identified, since vaccine shortages may preclude immunizing all of the state’s 100,000 emergency responders and health care personnel. Consideration should also be given to administration of vaccine to elementary, secondary, and post-secondary school students, who number almost a million in South Carolina and who may serve as points of entry for disease into the community.

 

Resources for determining priority list for vaccination:

 

·         Federal guidelines and published research

·         Surveillance data on novel strain  (CDC, WHO, DHEC Division of Epidemiology)

 

Suggested priorities for vaccine administration given limited supplies are the following:

(Also see Appendices A & B)

 

1)       First dose for all high priority groups

2)       Second dose for all high priority groups

3)       Private sector, with first administration to high priority groups (possibility may exist that sufficient supplies will be only enough to provide one dose for high priority individuals, and that there will be no “supplementary” vaccine available for private sector use.)

 

Sample criteria for release of vaccine to the private sector have been developed; the feasibility of adhering to and enforcing such criteria during a pandemic is uncertain.

 

A single dose vaccine strategy may need to be considered by the VPG if vaccine is in extremely short supply, in the interest of protecting more persons in priority and/or high risk groups.

 

An executive order on vaccine priority from the Governor’s office would follow recommendations of the standing advisory group. The priority list should be publicized once generated. Though some advance notice to public of who priority groups are and how decision was made will be necessary, shipment of vaccine to sites and administration of flu vaccine should be “unannounced” to the extent possible.

 

 

Vaccine Allocation, Distribution, and Selection of Sites for Vaccine Administration

 

Control of vaccine distribution by DHEC Immunization Division will help to insure equitable distribution to priority groups regardless of income or access to care and will also facilitate distribution of vaccine to essential community servants. All public sector vaccination would occur under DHEC auspices, bu